Gradients in surface nanotopography used to study platelet adhesion and activation

- Fabrication of gradients in surface nanotopography using gold nanoparticles.
- Monitoring of cell response to gradual increasing surface nanotopography.
- Activation and adhesion of human platelets is more sensitive to nanotopography than surface hydrophobicity.
- Platelet activation is not related to the amount of fibrinogen on nanostructured surfaces.