کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
702065 1460788 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Electrochemical determination of adrenaline in human urine using a boron-doped diamond film electrode
ترجمه فارسی عنوان
تعیین الکتروشیمیایی آدرنالین در ادرار انسان با استفاده از یک الکترود الماس بر روی بور
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه سایر رشته های مهندسی مهندسی برق و الکترونیک
چکیده انگلیسی


• BDDF electrode was employed for the first time for determination of adrenaline
• Detection limit of 0.21 μM was achieved without any modification of electrode
• Benefits of method: rapidity, simplicity, sensitivity and repeatability
• Electrochemical sensor for drug determination in various biological samples

A simple and sensitive square-wave voltammetric method for the determination of adrenaline on unmodified boron-doped diamond film electrode was developed. Adrenaline exhibited the quasi-reversible behavior with oxidation peak on the forward scan at + 0.75 V and smaller reduction peak on the reverse scan at − 0.10 V vs. Ag/AgCl electrode in 0.5 M HClO4. The effect of supporting electrolyte, pH and scan rate on the current response of adrenaline was examined to select the optimum experimental conditions. At optimized square-wave voltammetric parameters (amplitude of 100 mV, frequency of 50 Hz and step potential of 5 mV), the linear concentration range from 0.7 to 60 μM (R2 = 0.998, number of measurements n = 6), the excellent repeatability (relative standard deviation of 3.5% for n = 50) and the detection limit of 0.21 μM were achieved without any chemical modification and pretreatment of working electrode. The practical application of method was demonstrated in the determination of adrenaline in spiked human urine samples with satisfactory recoveries (98 to 102%).

Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Diamond and Related Materials - Volume 43, March 2014, Pages 5–11
نویسندگان
, , , ,