کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7079677 | 1459991 | 2014 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The relationship of oxygen uptake rate and kLa with rheological properties in high cell density cultivation of docosahexaenoic acid by Schizochytrium sp. S31
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
تکنولوژی و شیمی فرآیندی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Three independent cultures by fed batch strategy under different oxygen supply levels were investigated with Schizochytrium sp. S31 on glycerol in 50Â L bioreactor. Three cultures all achieved high cell density cultivation (HCDC) with more than 100Â g/L biomass density. However, the culture with middle oxygen supply level achieved the highest DHA concentration at 21.26Â g/L. Dissolved oxygen (DO) limitation was commonly encountered in the present cultures, which was due to the dramatic decrease of kLa in high oxygen supply culture resulted from significantly increasing apparent viscosity of the broth. The rheological properties of the three cultures all exhibited shear-thinning behavior. The oxygen uptake rate (OUR) predominately influenced by kLa was suggested to replace DO as on-line control parameter for scale-up production of DHA.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioresource Technology - Volume 152, January 2014, Pages 234-240
Journal: Bioresource Technology - Volume 152, January 2014, Pages 234-240
نویسندگان
Guifang Chang, Juan Wu, Cuihong Jiang, Guiwei Tian, Qinghang Wu, Ming Chang, Xingguo Wang,