کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7079912 | 1459991 | 2014 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Enhanced production of Fumigaclavine C in liquid culture of Aspergillus fumigatus under a two-stage process
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
تکنولوژی و شیمی فرآیندی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Enhanced production of Fumigaclavine C in liquid culture of Aspergillus fumigatus under a two-stage process Enhanced production of Fumigaclavine C in liquid culture of Aspergillus fumigatus under a two-stage process](/preview/png/7079912.png)
چکیده انگلیسی
Fumigaclavine C (FC) produced by Aspergillus fumigatus is a conidiation associated ergot alkaloid with strong anti-inflammatory activity. However, its wide application has been severely limited by low FC production from submerged culture. In this work, a novel two-stage culture process by combining shake culture with static culture was proposed to enhance the production of FC. After the process optimization, the FC production reached 62.7Â mg/L, which was significantly higher than ever report. For scaling up this new culture process, the gas-liquid interfacial area per unit volume (Agas-liq) was identified as the key factor. The results showed that in a combined stirred-static bioreactor system, a maximum FC production (58.97Â mg/L) was obtained at an Agas-liq value of 1.30Â cm2/mL. These results demonstrated that two-stage culture is an efficient strategy to enhance FC production and the information obtained will be useful to production of this powerful bioactive compound on a large scale.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioresource Technology - Volume 152, January 2014, Pages 162-168
Journal: Bioresource Technology - Volume 152, January 2014, Pages 162-168
نویسندگان
Yi-Xiang Zhu, Ling-Yun Yao, Rui-Hua Jiao, Yan-Hua Lu, Ren-Xiang Tan,