Mathematical modeling of poly[(R)-3-hydroxyalkanoate] synthesis by Cupriavidus necator DSM 545 on substrates stemming from biodiesel production

► Valuable mathematical models for PHA production by Cupriavidus necator on combined substrates. ► PHA production on waste substrates from biodiesel (FAME and glycerol). ► New low structured model for fed-batch fermentation on glucose with glycerol. ► New low structured model for fed-batch fermentation on FAME with valeric acid. ► In silico optimized feeding of C-sources and PHB/PHBV content by mathematical models.