An optimized industrial fermentation processes for acarbose production by Actinoplanes sp. A56

► Reported literatures of acarbose fermentation mainly focused on lab or pilot scale. ► We previously reported the scale-up acarbose fermentation by Actinoplanes sp. A56. ► Therefore, the industrial acarbose fermentation was further optimized in this paper. ► Five thousand milligrams per liters of acarbose was obtained, which was highest in all reported literatures.