Optimization of microalgal productivity using an adaptive, non-linear model based strategy

► Heterotrophic algal cultures were optimized using an adaptive model-based approach. ► Cell density reached a high value of 144 g/L and a lipid productivity of 20.16 g/L d. ► Reported oil productivity is higher than in other optimized oleaginous microbes. ► Produced algal oil has a high quality as biodiesel precursor. ► Heterotrophic algae has a great potential as a source of single cell oil or biodiesel.