Novel in situ product removal technique for simultaneous production of propionic acid and vitamin B12 by expanded bed adsorption bioreactor

► Applying expanded bed adsorption system to produce propionic acid and vitamin B12. ► ZGA330 resin was determined as the best resin by adsorption experiments. ► Biocompatibility was not problematic for EBA-based process. ► Inhibition of propionic acid on cell growth and vitamin B12 synthesis was reduced.