کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7229185 | 1470918 | 2018 | 23 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Patchy gold coated Fe3O4 nanospheres with enhanced catalytic activity applied for paper-based bipolar electrode-electrochemiluminescence aptasensors
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
In this work, novel multifunctional patchy gold coated Fe3O4 hybrid nanoparticles (PG-Fe3O4 NPs) have been successfully synthesized in aqueous medium via a facile adsorption-reduction method. A rational formation mechanism has been proposed by monitoring the morphological evolution. The PG-Fe3O4 NPs retained the good magnetic property and exhibited excellent catalytical effeciency towards the electrochemical reduction of hydrogen peroxide. Chronoamperometric and amperometric experiments indicated a relatively high catalytic rate constant of 3.13â¯Ãâ¯105 Mâ1 sâ1, a high sensitivity of 578.87â¯ÂµAâ¯mMâ1 cmâ2 and a low Michaelis-Menten constant of 462â¯ÂµM. Meanwhile, the introduction of patchy gold could help biofunctionalization via Au-S bond for different biodetection and biosensing purposes. Here, as an example, thiol-terminated aptamers were immobilized onto the patchy gold part as a signal probe to detect carcinoembryonic antigen (CEA). A related paper-based bipolar electrode-electrochemiluminescence (pBPE-ECL) aptasensor was fabricated as the low-cost, disposable and miniature platform. To improve the sensitivity, Au nanodendrites were electrodeposited at the BPE cathode as the matrix for Apt1 immobilization. This aptasensor showed a wide linear range of 0.1â¯pgâ¯mLâ1-15â¯ngâ¯mLâ1 with a low detection limit of 0.03â¯pgâ¯mLâ1, remaining competitive against other ones, and also demonstrating the PG-Fe3O4 NPs have promising potential for catalysis and bioassays.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biosensors and Bioelectronics - Volume 114, 30 August 2018, Pages 44-51
Journal: Biosensors and Bioelectronics - Volume 114, 30 August 2018, Pages 44-51
نویسندگان
Xin Zhang, Ning Bao, Xiliang Luo, Shou-Nian Ding,