کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7229628 | 1470925 | 2018 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
All-carbon suspended nanowire sensors as a rapid highly-sensitive label-free chemiresistive biosensing platform
ترجمه فارسی عنوان
سنسورهای نانوسیم معلق تمام کربن به عنوان یک پلت فرم بی حس کننده شیمیائی مقاوم در برابر حساسیت سریع بسیار حساس است
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
Nanowire sensors offer great potential as highly sensitive electrochemical and electronic biosensors because of their small size, high aspect ratios, and electronic properties. Nevertheless, the available methods to fabricate carbon nanowires in a controlled manner remain limited to expensive techniques. This paper presents a simple fabrication technique for sub-100â¯nm suspended carbon nanowire sensors by integrating electrospinning and photolithography techniques. Carbon Microelectromechanical Systems (C-MEMS) fabrication techniques allow fabrication of high aspect ratio carbon structures by patterning photoresist polymers into desired shapes and subsequent carbonization of resultant structures by pyrolysis. In our sensor platform, suspended nanowires were deposited by electrospinning while photolithography was used to fabricate support structures. We have achieved suspended carbon nanowires with sub-100â¯nm diameters in this study. The sensor platform was then integrated with a microfluidic chip to form a lab-on-chip device for label-free chemiresistive biosensing. We have investigated this nanoelectronics label-free biosensor's performance towards bacterial sensing by functionalization with Salmonella-specific aptamer probes. The device was tested with varying concentrations of Salmonella Typhimurium to evaluate sensitivity and various other bacteria to investigate specificity. The results showed that the sensor is highly specific and sensitive in detection of Salmonella with a detection limit of 10 CFUâ¯mLâ1. Moreover, this proposed chemiresistive assay has a reduced turnaround time of 5â¯min and sample volume requirement of 5â¯ÂµL which are much less than reported in the literature.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biosensors and Bioelectronics - Volume 107, 1 June 2018, Pages 145-152
Journal: Biosensors and Bioelectronics - Volume 107, 1 June 2018, Pages 145-152
نویسندگان
Aung Thiha, Fatimah Ibrahim, Shalini Muniandy, Ignatius Julian Dinshaw, Swe Jyan Teh, Kwai Lin Thong, Bey Fen Leo, Marc Madou,