کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7232852 | 1470967 | 2015 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Integrated catheter system for continuous glucose measurement and simultaneous insulin infusion
ترجمه فارسی عنوان
سیستم کاتتر یکپارچه برای اندازه گیری گلوکز مستمر و تزریق انسولین همزمان
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
A new measurement system enables combination of continuous glucose monitoring (CGM) and insulin infusion. A sensor system comprising an optical glucose biosensor and an optical oxygen sensor is integrated into the insulin infusion catheter of an insulin pump. Both sensors rely on near infrared (NIR) phosphorescent porphyrin dyes, wherefore the signals can be read out transcutaneous and non-invasively with a custom-built phase fluorometer measurement module. The spectral properties of the indicator dyes and the optical setup of the measurement module were optimized to enable independent read-out in two channels. Dynamic ranges from 0Â mmHg to 160Â mmHg oxygen and 0Â mg/dL to 360Â mg/dL glucose (LOD 2Â mg/dL) are covered by the oxygen and the glucose sensor, respectively. In-vivo measurements in pigs demonstrate good correlation of reference blood glucose levels and glucose values obtained with the presented sensor system. The evaluation of the clinical accuracy of the system with Clarke Error Grid Analysis showed similar results to CGM-devices currently on the market.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biosensors and Bioelectronics - Volume 64, 15 February 2015, Pages 102-110
Journal: Biosensors and Bioelectronics - Volume 64, 15 February 2015, Pages 102-110
نویسندگان
Barbara Nacht, Christoph Larndorfer, Stefan Sax, Sergey M. Borisov, Martin Hajnsek, Frank Sinner, Emil J.W. List-Kratochvil, Ingo Klimant,