کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7232856 1470967 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Distinguish cancer cells based on targeting turn-on fluorescence imaging by folate functionalized green emitting carbon dots
ترجمه فارسی عنوان
تشخیص سلول های سرطانی براساس هدف قرار دادن تصویربرداری فلورسنت روشن با نقاط کربن سبب انتشار فولات
کلمات کلیدی
جدا کردن سلول های سرطانی، روشن کردن فلورسانس، تصویربرداری هدفمند، نقطه کربن، سبز،
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
Developing efficient methods for visual detection of cancer cells has the potential to contribute greatly to basic biological research and early diagnosis of cancer. Here, we report facile and one-step synthesis of green fluorescence carbon dots (CDs) with the help of a new passivating agent - poly(acrylate sodium) (PAAS). Based on the as-prepared CDs, a novel turn-on fluorescence probe was designed for targeting imaging of cancer cells via hydrogen-bond interaction between folic acid and CDs (FA-CDs). Intracellular experiments indicated that FA-CDs probe could accurately distinguish folate receptor (FR)-positive cancer cells in different cell mixtures with turn-on mode. In particular, combining the targeting of FA-CDs probe with the excellent photostability of CDs has inestimable meaning for fluorescence-assisted surgical resection and acquisition real-time information about tumor cells. Obviously, the as-prepared FA-CDs probe may have great potential as a high-performance platform for accurately recognizing special cancer cells, which may provide new tools for cancer prognosis and therapy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biosensors and Bioelectronics - Volume 64, 15 February 2015, Pages 119-125
نویسندگان
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