کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7233701 | 1470981 | 2013 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Highly sensitive and selective phosphorescent chemosensors for hypochlorous acid based on ruthenium(II) complexes
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Microbicidal activity of hypochlorous acid (HOCl) plays pivotal roles in many biological processes, and suitable methods for the in vivo detection of HOCl are highly desirable. Herein we report the development of two novel ruthenium(II) complex-based phosphorescent chemosensors for HOCl, [Ru(bpy)2(DNCA-bpy)](PF6)2 (bpy: 2,2â²-bipyridine; DNCA-bpy: 4-N-(2,4-dinitrophenyl)carboxamide-4â²-methyl-2,2â²-bipyridine) and [Ru(bpy)2(DNCH-bpy)](PF6)2 (DNCH-bpy: 4-Nâ²-(2,4-dinitrophenyl)carbohydrazide-4â²-methyl-2,2â²-bipyridine). The two sensors are almost non-luminescent due to the intramolecular photoinduced electron transfer (PET) process from the Ru(II)-bpy moiety to dinitrophenyl group, but specific reaction of the sensors with HOCl in aqueous media can afford a highly luminescent derivative, [Ru(bpy)2(COOH-bpy)](PF6)2 (COOH-bpy: 4-carboxylic acid-4â²-methyl-2,2â²-bipyridine), accompanied by 190-fold and 1100-fold turn-on luminescence signal enhancement for [Ru(bpy)2(DNCA-bpy)](PF6)2 and [Ru(bpy)2(DNCH-bpy)](PF6)2, respectively. By taking advantage of high specificity and sensitivity of the chemosensor and excellent photophysical property of Ru(II) complex, [Ru(bpy)2(DNCH-bpy)](PF6)2 was applied for visualizing the endogenous HOCl generation in living macrophage cells during the processes of stimulation and phagocytosis via the red-emitting luminescence.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biosensors and Bioelectronics - Volume 50, 15 December 2013, Pages 1-7
Journal: Biosensors and Bioelectronics - Volume 50, 15 December 2013, Pages 1-7
نویسندگان
Run Zhang, Bo Song, Zhichao Dai, Zhiqiang Ye, Yunna Xiao, Yan Liu, Jingli Yuan,