کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7233988 | 1470981 | 2013 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A highly sensitive and label free biosensing platform for wireless sensor node system
ترجمه فارسی عنوان
یک پلت فرم بی حس کننده بسیار حساس و برچسب رایگان برای سیستم گره حسگر بی سیم
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
In this paper, we propose a radio-frequency (RF) biosensor platform based on oscillation frequency deviation at 2.4Â GHz. Its feasibility is experimentally demonstrated with the well-known biomolecular binding systems such as biotin-streptavidin and deoxyribonucleic acid (DNA) hybridization. For a basic principle of our biosensing system, the impedance of a resonator with the biomolecular immobilization is at first varied so that the corresponding change results in frequency change of an oscillator. Especially, to enhance the sensitivity of the proposed system, a surface acoustic wave (SAW) filter having a high-Q factor (~2000) is utilized. From the resulting component, even a small change of oscillation frequency can be transformed into a large output amplitude variation. According to the experimental results, it is found that our system shows the low detectable limit (~1Â ng/ml) and fast response time (~real-time) for different target biomolecules, i.e. streptavidin and complementary DNA (cDNA). As a result, we find that our device is an effective biosensing system that can be used for a label-free and real-time measurement of the biomolecular binding events.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biosensors and Bioelectronics - Volume 50, 15 December 2013, Pages 362-367
Journal: Biosensors and Bioelectronics - Volume 50, 15 December 2013, Pages 362-367
نویسندگان
Sang-Gyu Kim, Hee-Jo Lee, Jung-Hyun Lee, Hyo-Il Jung, Jong-Gwan Yook,