Sensitive detection of rutin with novel ferrocene benzyne derivative modified electrodes

► A new ferrocene benzyne derivative (Fc-SAc) was firstly synthesized. ► Fc-SH was immobilized onto AuNPs modified electrodes for rutin detection. ► Sensitive detection of rutin resulted from synergy signal enhancement of nanomaterial and Fc-SAc. ► Two Fc-SAc modified electrodes showed excellent performance in rutin detection.