Graphene oxide-hairpin probe nanocomposite as a homogeneous assay platform for DNA base excision repair screening

► A novel biosensor for activity analysis of uracil-DNA glycosylase. ► A graphene oxide-hairpin probe nanocomposite was constructed in this strategy. ► Simple, cost-effective, highly sensitive and selective assay was achieved. ► A promising homogeneous platform for UDG assay and related biochemical studies.