Clinical ultrasound stimulating angiogenesis following drug-release from polymersomes on the ischemic zone for peripheral arterial occlusive disease

Cilostazol-loaded Fe3O4-PLGA polymersomes provided the ability of magnet-induced accumulation in ischemia leg and ultrasound-responsive drug release for treatment of peripheral arterial occlusive disease. Dramatically, we found an observable result of bloody flux recovery in the leg after 7 days compared to the non-treated leg that showed no evidence of the blood recovery.203