Apigenin loaded nanoparticle delayed development of hepatocellular carcinoma in rats

Apigenin loaded PLGA nanoparticles successfully delayed hepatocellular carcinoma both in-vitro and in-vivo. Such strategic formulation of apigenin improved its bioavailability and made it more tumor site specific in nature. Again, various pharmacokinetic parameters and biodistribution of apigenin in mice plasma and liver were measured using LC-MS/MS and radiolabeling study. This study may help us to promote the usage of nanoformulations of dietary flavonoids such as apigenin in combating HCC along with the other medicines available in market.343