Co-delivery of docetaxel and gemcitabine using PEGylated self-assembled stealth nanoparticles for improved breast cancer therapy

Dual-drug stealth amphiphilic conjugate (DTX-PEG-GEM) self-assembled to form NPs resulting in enhanced cellular uptake via clathrin mediated endocytosis, independent of nuclear transporters (hNTs), Organic Anion Transporting Polypeptides (OATPs) for GEM and DTX, respectively.217