CD44 directed nanomicellar payload delivery platform for selective anticancer effect and tumor specific imaging of triple negative breast cancer

This image indicates the development of CD44 selective HA-SMA-TPGS oligomer and encapsulation of CDF to form HA-SMA-TPGS-CDF nano-micelle. The HA-SMA-TPGS oligomer was ligated with near infrared dye for imaging of TNBC. The HA-SMA-TPGS-CDF showed significantly higher tumor cell killing effect as compared to SMA-TPGS or CDF treatment through up-regulation of tumoricidal PTEN protein and down-regulation of tumorigenic NF-κB protein, resulting in induction of apoptosis. The cell uptake study of HA-SMA-TPGS-rhodamine demonstrates TNBC cell selective endocytosis. Overall the purpose of study is to demonstrate CD44 selective TNBC imaging and pronounced cell killing.323