Metallic gold and bioactive quinacrine hybrid nanoparticles inhibit oral cancer stem cell and angiogenesis by deregulating inflammatory cytokines in p53 dependent manner

Figure shows the incorporation of PLGA coated QAuNP in OSCC-CSCs leading to up-regulation of p53 and p21. Up-regulated p53 and p21 lead to reduction of pro-inflammatory cytokines i.e. IL-6, IL-8, IL-1β, TNF-α leading to anti-inflammatory action. Further up-regulated p53 and p21 induced mitochondrial damage by increasing ROS and NO and inhibited angiogenesis by down-regulating Ang-1, Ang-2, VEGF, MMP-2 and MMP-9.263