Sensing adhesion forces between erythrocytes and γ' fibrinogen, modulating fibrin clot architecture and function

Comparison of the interaction between red blood cells (RBCs) and γAγA or γAγ' fibrinogen. Schematic representation of the adhesion forces between two RBCs in the presence of γAγ' fibrinogen, which affects clot properties and function. Changes on fibrin network structure, decreased fiber diameter, increased fibrinolysis and decreased permeability by γAγ' fibrinogen-RBC interactions were encountered. The nanotechnology-based approach was essential to understand that the RBCs interact differently with clots made with γ' chain fibrinogen splice variant instead of the common variant, γA. This may explain some of the cardiovascular clinical associations that have been reported for γ' fibrinogen.111