Doxorubicin-loaded dendritic-Fe3O4 supramolecular nanoparticles for magnetic drug targeting and tumor regression in spheroid murine melanoma model

In addition to excellent drug delivery performances, dendrimer-functionalized Fe3O4 nanoparticles are a promising candidate for magnetic drug targeting in tumor models in vivo. Our drug-loaded dendritic-Fe3O4 nanoparticles show elevated tumor localization under an external permanent magnetic field which results in high drug accumulation in subcutaneous melanoma. The magnetic field facilitates this passive localization as high as 6-fold resulting in substantial tumor regression and growth inhibition. The tumor disappears after 20 days, post-treatment, with no relapse and ~100% mice survival for a study period of 60 days.271