Cerenkov luminescence imaging on evaluation of early response to chemotherapy of drug-resistant gastric cancer

68Ga-DOTA-Annexin V was prepared as the apoptosis targeting probe. Xenografts constructed with wild type SGC7901/WT and its vincristine-resistant variant SGC7901/VCR simulated the situation of treatment decision. In vivo CLI imaging of apoptosis correlated with chemotherapy outcomes. Stronger signal of apoptosis imaging of CLI correlated with the shrinkage of tumor volumes of successful treatment of cisplatin to SGC7901/VCR xenografts. In vivo CLI imaging with Cerenkov radiance-emitting apoptosis-targeting probe is a promising technique for in vivo apoptosis imaging.158