Electrospray differential mobility analysis for nanoscale medicinal and pharmaceutical applications

Electrospray differential mobility analysis (ES-DMA) is an emerging tool that rapidly provides macromolecular size distributions from ~ 1 nm to < 500 nm. It detects and quantifies lipoproteins, glycoproteins (including IgM shown herein), viruses and amyloid fibrillation, inter alia. ES-DMA only requires 30 μL for each run and is a label-free method that accurately provides subnanometer precision.165