کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7278401 | 1473855 | 2016 | 32 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cognitive endophenotypes of attention deficit/hyperactivity disorder and intra-subject variability in patients with autism spectrum disorder
ترجمه فارسی عنوان
اندوفنوتایپ های شناختی اختلال نقص توجه / بیش فعالی و تغییرات درون فردی در بیماران مبتلا به اختلال طیف اوتیسم
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کلمات کلیدی
Endophenotype - آندوفنوتیپ autism spectrum disorders - اختلالات طیف اوتیسمAutism - اوتیسم یا درخودماندگیInhibition - بازداریADHD - بیشفعالیIntra-subject variability - تنوع درونی موضوعWorking memory - حافظه فعال یا حافظه کاریTemporal processing - پردازش موقتیAttention deficit/hyperactivity disorder - کمبود توجه / اختلال بیش فعالی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
چکیده انگلیسی
Autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) have previously been studied mainly in isolation from each other. However the two conditions may be aetiologically related and thus show overlap in aetiologically relevant functions. In order to address this question of potential aetiological overlap between ADHD and ASD, the present study set out to investigate putative endophenotypes of ADHD in NÂ =Â 33 typically developing (TD) children and NÂ =Â 28 patients with ASD that were (ASD+) or were not (ASDâ) co-morbid for ADHD. With regard to both the cognitive endophenotype candidates (working memory, inhibition, temporal processing) and intra-subject variability (ISV) the pattern of abnormalities was inconsistent. Furthermore, the overall profile of ASD-TD differences was extremely similar to the pattern of differences between the ASD+ and ASDâ sub-groups, suggesting that any abnormalities found were due to the comorbid ASD subgroup. This held in particular for ISV, which did not show in patients with ASD the task-general increase that is common in ADHD samples. Altogether, the present results do not support the hypothesis of aetiological overlap between ASD and ADHD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biological Psychology - Volume 118, July 2016, Pages 25-34
Journal: Biological Psychology - Volume 118, July 2016, Pages 25-34
نویسندگان
M. Biscaldi, N. Bednorz, K. Weissbrodt, C.W.N. Saville, B. Feige, S. Bender, C. Klein,