کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7282703 | 1473948 | 2018 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Modeling cognitive deficits following neurodegenerative diseases and traumatic brain injuries with deep convolutional neural networks
ترجمه فارسی عنوان
مدل سازی نقص شناختی پس از بیماری های نورولوژیک و آسیب های مغزی آسیب دیده با شبکه های عصبی پیچیده عمیق
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب شناختی
چکیده انگلیسی
The accurate diagnosis and assessment of neurodegenerative disease and traumatic brain injuries (TBI) remain open challenges. Both cause cognitive and functional deficits due to focal axonal swellings (FAS), but it is difficult to deliver a prognosis due to our limited ability to assess damaged neurons at a cellular level in vivo. We simulate the effects of neurodegenerative disease and TBI using convolutional neural networks (CNNs) as our model of cognition. We utilize biophysically relevant statistical data on FAS to damage the connections in CNNs in a functionally relevant way. We incorporate energy constraints on the brain by pruning the CNNs to be less over-engineered. Qualitatively, we demonstrate that damage leads to human-like mistakes. Our experiments also provide quantitative assessments of how accuracy is affected by various types and levels of damage. The deficit resulting from a fixed amount of damage greatly depends on which connections are randomly injured, providing intuition for why it is difficult to predict impairments. There is a large degree of subjectivity when it comes to interpreting cognitive deficits from complex systems such as the human brain. However, we provide important insight and a quantitative framework for disorders in which FAS are implicated.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain and Cognition - Volume 123, June 2018, Pages 154-164
Journal: Brain and Cognition - Volume 123, June 2018, Pages 154-164
نویسندگان
Bethany Lusch, Jake Weholt, Pedro D. Maia, J. Nathan Kutz,