کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7298998 1475142 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Rapid reversal of translational silencing: Emerging role of microRNA degradation pathways in neuronal plasticity
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Rapid reversal of translational silencing: Emerging role of microRNA degradation pathways in neuronal plasticity
چکیده انگلیسی
As microRNAs silence translation, rapid reversal of this process has emerged as an attractive mechanism for driving de novo protein synthesis mediating neuronal plasticity. Herein, we summarize recent studies identifying neuronal stimuli that trigger rapid decreases in microRNA levels and reverse translational silencing of plasticity transcripts. Although these findings indicate that neuronal stimulation elicits rapid degradation of selected microRNAs, we are only beginning to decipher the molecular pathways involved. Accordingly, we present an overview of several molecular pathways implicated in mediating microRNA degradation: Lin-28, translin/trax, and MCPIP1. As these degradation pathways target distinct subsets of microRNAs, they enable neurons to reverse silencing rapidly, yet selectively.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Learning and Memory - Volume 133, September 2016, Pages 225-232
نویسندگان
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