کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7299972 1475159 2014 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Treadmill exercise alters histone acetylation differently in rats exposed or not exposed to aversive learning context
ترجمه فارسی عنوان
ورزش تردمیل استیلاسیون هیستون را تغییر می دهد در موش هایی که در معرض آن قرار دارند یا در معرض آن قرار ندارند
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
چکیده انگلیسی
Epigenetic modifications have been linked to memory formation after learning context exposure and to exercise effects on memory performance. The aim of this study was to investigate the effect of treadmill exercise (20 min/day during 2 weeks) on H3K14 acetylation and H3S10 phosphorylation levels in the hippocampi of 3-month-old Wistar rats exposed and not exposed to aversive learning context. Male Wistar rats aged 2-3 months were assigned to non-exercised (sedentary) and exercised (running daily for 20 min for 2 weeks) groups. Single-trial step-down inhibitory avoidance (IA) conditioning was employed as an aversive memory model. Epigenetic parameters were determined 30 min after the IA test. A decrease in the H3K14 acetylation in the hippocampus 24 h after IA training (30 min after test session) was observed. Exercise reversed the IA effect, and no effect was observed in the non-IA exposed group. Our data support the hypothesis that modulation of H3K14 acetylation levels in the hippocampus might be related, at least in part, to exercise effects on aversive memory.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Learning and Memory - Volume 116, December 2014, Pages 193-196
نویسندگان
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