کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7300420 | 1475166 | 2014 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Sleep deprivation during a specific 3-hour time window post-training impairs hippocampal synaptic plasticity and memory
ترجمه فارسی عنوان
محرومیت از خواب در طی یک دوره زمانی مشخص 3 ساعته پس از تمرین، پلاستیک و حافظه سیناپسی هیپوکامپ را مختل می کند
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کلمات کلیدی
از دست دادن خواب، پتانسیل بلندمدت، هیپوکامپ، حافظه فضایی،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
چکیده انگلیسی
Sleep deprivation disrupts hippocampal function and plasticity. In particular, long-term memory consolidation is impaired by sleep deprivation, suggesting that a specific critical period exists following learning during which sleep is necessary. To elucidate the impact of sleep deprivation on long-term memory consolidation and synaptic plasticity, long-term memory was assessed when mice were sleep deprived following training in the hippocampus-dependent object place recognition task. We found that 3Â h of sleep deprivation significantly impaired memory when deprivation began 1Â h after training. In contrast, 3Â h of deprivation beginning immediately post-training did not impair spatial memory. Furthermore, a 3-h sleep deprivation beginning 1Â h after training impaired hippocampal long-term potentiation (LTP), whereas sleep deprivation immediately after training did not affect LTP. Together, our findings define a specific 3-h critical period, extending from 1 to 4Â h after training, during which sleep deprivation impairs hippocampal function.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Learning and Memory - Volume 109, March 2014, Pages 122-130
Journal: Neurobiology of Learning and Memory - Volume 109, March 2014, Pages 122-130
نویسندگان
Toni-Moi Prince, Mathieu Wimmer, Jennifer Choi, Robbert Havekes, Sara Aton, Ted Abel,