کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7300492 1475170 2013 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
On the potential role of active DNA demethylation in establishing epigenetic states associated with neural plasticity and memory
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
On the potential role of active DNA demethylation in establishing epigenetic states associated with neural plasticity and memory
چکیده انگلیسی
Dynamic variations in DNA methylation regulate neuronal gene expression in an experience-dependent manner. Although DNA methylation has been implicated in synaptic plasticity, learning and memory, active DNA demethylation is also induced by learning, which suggests that an interaction between the two processes is necessary for cognitive function. Active DNA demethylation is a complex process involving a variety of proteins and epigenetic regulatory enzymes, the understanding of which with respect to its role in the adult brain is in its infancy. We here provide an overview of the current understanding of active DNA demethylation, and describe how this process may establish persistent epigenetic states that are associated with neural plasticity and memory formation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Learning and Memory - Volume 105, October 2013, Pages 125-132
نویسندگان
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