Effects of levetiracetam, an antiepileptic drug, on memory impairments associated with aging and Alzheimer's disease in mice

► Pretraining administration of levetiracetam reverses memory decline in aged mice. ► Levetiracetam injected immediately after training also improves memory in aged mice. ► Levetiracetam given at a later posttraining interval (3 h) has no effect in aged mice. ► Pretraining levetiracetam does not rescue memory deficits in Alzheimer's model mice.