Object recognition memory and temporal lobe activation after delayed estrogen replacement therapy

- The object recognition memory decays along 12 weeks of OVX.
- Delayed estrogen replacement therapy rescues the object recognition memory deficit of OVX female mice.
- Delayed estrogen replacement therapy upregulates c-Fos expression in the hippocampus, amygdala and perirhinal cortex.
- Delayed estrogen replacement therapy induces object-dependent activation of the perirhinal cortex.
- Delayed estrogen replacement therapy induces object-dependent activation of the central nucleus of the amygdala.