Neuronal expression of the ubiquitin E3 ligase APC/C-Cdh1 during development is required for long-term potentiation, behavioral flexibility, and extinction

► Neuron-specific deletion of Cdh1 causes impaired L-LTP. ► Neuron-specific deletion of Cdh1 causes impaired reversal learning. ► Neuron-specific deletion of Cdh1 causes impaired extinction of fear memory.