Epigenetic regulation of reelin and brain-derived neurotrophic factor genes in long-term potentiation in rat medial prefrontal cortex

► In the medial prefrontal cortex (mPFC), long-term potentiation (LTP) can be induced. ► LTP enhances the demethylation status of reelin and bdnf genes in the mPFC. ► LTP also enhances the histone acetylation status of reelin and bdnf genes in the mPFC. ► 5-Azacytidine (DNA methyltransferase inhibitor) disrupts LTP and trace fear memory. ► Sodium butyrate (histone deacetylases inhibitor) enhances LTP and trace fear memory.