In vitro hippocampal gamma oscillation power as an index of in vivo CA3 gamma oscillation strength and spatial reference memory

► CA3 gamma oscillation strength in freely moving mice correlates with CA3 gamma oscillation strength in hippocampal slice models. ► CA3 gamma oscillation strength correlates with performance in spatial reference memory tasks. ► In vitro CA3 gamma oscillation strength can be used as a neurophysiological index of spatial reference memory.