Working memory task decreases the survival of newly born neurons in hippocampus

► Reference memory task (hidden platform water maze) promoted neurogenesis. ► Working memory task (delayed matching-to-place water maze) decreased neurogenesis. ► Both tasks lead to increase in serum corticosterone levels. ► Both tasks did not change BDNF and Notch 1 receptor level in hippocampus. ► Working memory task has different effects on survival of immature neurons.