کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7303575 | 1475315 | 2015 | 15 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Inflammation in schizophrenia: A question of balance
ترجمه فارسی عنوان
التهاب در اسکیزوفرنی: سوال تعادل
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کلمات کلیدی
جنون جوانی، روانپریشی التهاب استرس اکسیداتیو، سیستم ایمنی، داروهای ضد التهابی،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
چکیده انگلیسی
In the past decade, there has been renewed interest in immune/inflammatory changes and their associated oxidative/nitrosative consequences as key pathophysiological mechanisms in schizophrenia and related disorders. Both brain cell components (microglia, astrocytes, and neurons) and peripheral immune cells have been implicated in inflammation and the resulting oxidative/nitrosative stress (O&NS) in schizophrenia. Furthermore, down-regulation of endogenous antioxidant and anti-inflammatory mechanisms has been identified in biological samples from patients, although the degree and progression of the inflammatory process and the nature of its self-regulatory mechanisms vary from early onset to full-blown disease. This review focuses on the interactions between inflammation and O&NS, their damaging consequences for brain cells in schizophrenia, the possible origins of inflammation and increased O&NS in the disorder, and current pharmacological strategies to deal with these processes (mainly treatments with anti-inflammatory or antioxidant drugs as add-ons to antipsychotics).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience & Biobehavioral Reviews - Volume 55, August 2015, Pages 612-626
Journal: Neuroscience & Biobehavioral Reviews - Volume 55, August 2015, Pages 612-626
نویسندگان
Juan C. Leza, Borja GarcÃa-Bueno, Miquel Bioque, Celso Arango, Mara Parellada, Kim Do, Patricio O'Donnell, Miguel Bernardo,