کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7375096 | 1480067 | 2018 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Thermal-induced folding and unfolding of a transmembrane protein (CorA)
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
ریاضیات
فیزیک ریاضی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Thermal response of the inner (iCorA) and outer (oCorA) segments of a transmembrane protein CorA is investigated by a large-scale coarse-grained Monte Carlo simulation in native phase. We find that the conformation of iCorA contracts on raising the temperature, in contrast to its thermal response in denatured phase. The conformational response of the oCorA in its native phase appears to be less organized but differs considerably from that in its denatured phase where an abrupt increase of its radius of gyration occurs in a narrow temperature range. The inner segment (iCorA) retains its globular conformation in native phase while oCorA resorts to random-coil configurations with some coagulations on raising the temperature.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Physica A: Statistical Mechanics and its Applications - Volume 506, 15 September 2018, Pages 987-992
Journal: Physica A: Statistical Mechanics and its Applications - Volume 506, 15 September 2018, Pages 987-992
نویسندگان
Sunan Kitjaruwankul, Panisak Boonamnaj, Sunita Subedi Paudel, Warin Jetsadawisut, Pornthep Sompornpisut, R.B. Pandey,