کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7381965 1480178 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dynamics of cell aggregates fusion: Experiments and simulations
ترجمه فارسی عنوان
دینامیک ترکیب فیبرهای سلولی: آزمایش ها و شبیه سازی ها
موضوعات مرتبط
مهندسی و علوم پایه ریاضیات فیزیک ریاضی
چکیده انگلیسی
Fusion of cell tissues is an ubiquitous phenomenon and has important technological applications including tissue biofabrication. In this work we present experimental results of aggregates fusion using adipose derived stem cells (ADSC) and a three dimensional computer simulation of the process using the cellular Potts model with aggregates reaching 10,000 cells. We consider fusion of round aggregates and monitor the dimensionless neck area of contact between the two aggregates to characterize the process, as done for the coalescence of liquid droplets and polymers. Both experiments and simulations show that the evolution of this quantity obeys a power law in time. We also study quantitatively individual cell motion with the simulation and it corresponds to an anomalous diffusion.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Physica A: Statistical Mechanics and its Applications - Volume 395, 1 February 2014, Pages 247-254
نویسندگان
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