Corrected QT interval during treatment with methadone and buprenorphine-Relation to doses and serum concentrations

These results support and extend previous findings that treatment with methadone in modest doses (i.e. below 100 mg/d) is not associated with clinically significant QTc increases, and that buprenorphine in commonly used doses is a suitable alternative to methadone with regard to the risk of QTc prolongation.