The crystal structure of ADP-L-glycero-D-manno-heptose-6-epimerase (HP0859) from Helicobacter pylori

► LPS play an important role in maintaining the integrity of Gram-negative bacteria. ► HP0859 of Helicobacter pylori is a key enzyme in the biosynthesis of core LPS. ► Crystal structure of HP0859 reveals that the enzyme is a homo-pentamer. ► Each monomer presents two domains, a nucleotide- and a substrate- binding domain. ► NAD is bound as a cofactor.