The effect of deleting residue C269 in the β12-β13 loop of protein phosphatase 2A (PP2A)catalytic subunit on the interaction between PP2A and metal ions, especially Mn2+

► The deletion of Cys269 in PP2AC influences the activity of the PP2AD and changes the 3D structure of PP2AC. ► Cys269 deletion affects the interaction between PP2A and metal ions, especially Mn2+. ► C269 adjusts the polarity of the β12-β13 loop of PP2AC.