کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7585809 | 1492040 | 2018 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Simple and rapid determination of 5-nitroimidazoles and metabolites in fish roe samples by salting-out assisted liquid-liquid extraction and UHPLC-MS/MS
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
A novel multiresidue method is proposed for the determination of 12 5-nitroimidazoles and their metabolites in fish roe samples using UHPLC-MS/MS. A salting-out assisted liquid-liquid extraction procedure was performed prior to sample analysis. The separation of compounds was accomplished using a C18 Zorbax Eclipse Plus column (50â¯mmâ¯Ãâ¯2.1â¯mm, 1.8â¯Âµm) at 25â¯Â°C and a mobile phase consisting of 0.025% (v/v) aqueous formic acid and pure MeOH at a flow rate of 0.5â¯mL/min. Parameters involved in ionization and fragmentation were also optimized. The method was characterized in terms of linearity (R2â¯â¥â¯0.9992), extraction efficiency (â¥68.9%), repeatability (RSDâ¯â¤â¯9.8%), reproducibility (RSDâ¯â¤â¯13.9%) and trueness (recoveries â¥81.4%). Decision limits (CCα) and detection capabilities (CCβ) were obtained in the ranges 0.1-1.0 and 0.2-1.7â¯Âµg/kg, respectively.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food Chemistry - Volume 252, 30 June 2018, Pages 294-302
Journal: Food Chemistry - Volume 252, 30 June 2018, Pages 294-302
نویسندگان
Maykel Hernández-Mesa, Carmen Cruces-Blanco, Ana M. GarcÃa-Campaña,