کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7588408 | 1492081 | 2016 | 35 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Bioavailability of anthocyanins and colonic polyphenol metabolites following consumption of aronia berry extract
ترجمه فارسی عنوان
بیوپلاستی آنتوسیانین ها و متابولیت های پلی فنول کلینیکی پس از مصرف عصاره آرونی توت
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
A single-dose pharmacokinetic trial was conducted in 6 adults to evaluate the bioavailability of anthocyanins and colonic polyphenol metabolites after consumption of 500 mg aronia berry extract. UHPLC-MS methods were developed to quantitate aronia berry polyphenols and their metabolites in plasma and urine. While anthocyanins were bioavailable, microbial phenolic catabolites increased â¼10-fold more than anthocyanins in plasma and urine. Among the anthocyanins, cyanidin-3-O-galactoside was rapidly metabolized to peonidin-3-O-galactoside. Aronia polyphenols were absorbed and extensively metabolized with tmax of anthocyanins and other polyphenol catabolites from 1.0 h to 6.33 h in plasma and urine. Despite significant inter-individual variation in pharmacokinetic parameters, concentrations of polyphenol metabolites in plasma and urine at 24 h were positively correlated with total AUC in plasma and urine (r = 0.93, and r = 0.98, respectively). This suggests that fasting blood and urine collections could be used to estimate polyphenol bioavailability and metabolism after aronia polyphenol consumption.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food Chemistry - Volume 211, 15 November 2016, Pages 860-868
Journal: Food Chemistry - Volume 211, 15 November 2016, Pages 860-868
نویسندگان
Liyang Xie, Sang Gil Lee, Terrence M. Vance, Ying Wang, Bohkyung Kim, Ji-Young Lee, Ock K. Chun, Bradley W. Bolling,