کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7589203 | 1492090 | 2016 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cytotoxic monacolins from red yeast rice, a Chinese medicine and food
ترجمه فارسی عنوان
موناکولین سیتوتوکسیک از برنج مخمر قرمز، یک دارو چینی و غذا
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کلمات کلیدی
برنج مخمر قرمز، موناکولینها، سمیت مسمومیت،
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
Seven new monacolins, monacolins Q-S (1-3), α,β-dehydromonacolin S (4), 3α-hydroxy-3,5-dihydromonacolin L (5), 3β-hydroxy-3,5-dihydromonacolin L (6), and α,β-hydromonacolin Q (7) were isolated and characterized from the methanol extract of red yeast rice. In addition, six known monacolins, α,β-dehydrodihydromonacolin K (8), dehydromonacolin K (9), dehydromonacolin L (10), monacolin K (11), dihydromonacolin K (12), dihydromonacolin L (13) and two compounds other than monacolins (14, 15) were also isolated. Structure elucidation of the isolates was achieved by means of NMR and mass spectroscopic data analyses. Compounds 1-5, 8, 9, 11, and 13 were evaluated for their cytotoxic activity against four cancer cell lines (SK-MEL, KB, BT-549, SK-OV-3) and two noncancerous kidney cell lines (LLC-PK1 and Vero). Monacolin Q (1), monacolin R (2) α,β-dehydrodihydromonacolin K (8), dehydromonacolin K (9), and monacolin K (11) showed cytotoxicity to most of these cell lines in terms of inhibition of cell proliferation. The cytotoxicity of monacolin K (11) was the most potent among all the tested monacolins.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food Chemistry - Volume 202, 1 July 2016, Pages 262-268
Journal: Food Chemistry - Volume 202, 1 July 2016, Pages 262-268
نویسندگان
Zhihao Zhang, Zulfiqar Ali, Shabana I. Khan, Ikhlas A. Khan,