The chemopreventive effect of β-cryptoxanthin from mandarin on human stomach cells (BGC-823)

► β-Cryptoxanthin exhibited a dose-dependent anti-proliferative activity on BGC-823. ► β-Cryptoxanthin suppressed the cell migration as measured by scratch assay. ► We examined significant variations in cell cycle and its regulators. ► β-Cryptoxanthin restrained the expression of cyclin D1, cyclin E and induced p21. ► β-Cryptoxanthin induced the mRNA levels of retinoic acid receptor β (RARβ).