Hydroxytyrosyl ethyl ether exhibits stronger intestinal anticarcinogenic potency and effects on transcript profiles compared to hydroxytyrosol

► Hydroxytyrosol and hydroxytyrosyl ethyl ether alter genes related with colon cancer prevention in a dose dependent manner. ► Both polyphenols arrest cell cycle, induce apoptosis and enhance carcinogen detoxification. ► Hydroxytyrosyl ethyl ether shows more anticarcinogenic colorectal activity than its precursor, hydroxytyrosol.