Simultaneous determination of lercanidipine, benazepril and benazeprilat in plasma by LC-MS/MS and its application to a toxicokinetics study

► Simultaneous determination of LER, BEN and benazeprilat in plasma with single IS. ► The method was fully validated to meet the requirements of FDA and GCP guidelines. ► It can meet the requirement in analyzing large number of samples from clinical trials.