کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7622101 | 1494522 | 2018 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pyrrole alkaloids and ergosterols from Grifola frondosa exert anti-α-glucosidase and anti-proliferative activities
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Pyrrole alkaloids and ergosterols from Grifola frondosa exert anti-α-glucosidase and anti-proliferative activities Pyrrole alkaloids and ergosterols from Grifola frondosa exert anti-α-glucosidase and anti-proliferative activities](/preview/png/7622101.png)
چکیده انگلیسی
Previously, polysaccharides with hypoglycemic effects from G. frondosa were reported by us. To explore compounds against α-glucosidase and human tumor cells, three extractive fractions (GF-1-GF-3) were prepared from G. frondosa ethanol extraction (GF) by chromatographic column. Rather than GF-1 and GF-2, the fraction GF-3 demonstrated inhibitory actions against α-glucosidase and proliferation of human tumor cells dominantly. To identify the bioactive compounds in GF-3, one new compound named pyrrolefronine together with 19 known ones, which included seven pyrrole alkaloids, nine ergosterols and three others, were isolated and characterized from GF-3. Significantly, pyrrole alkaloids were found in G. frondosa for the first time, showing potent inhibition against α-glucosidase. Obtained ergosterols displayed inhibition against proliferation of tumor cells. This study provides a basis for further development and utilization of G. frondosa as natural nutraceuticals and functional food ingredients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 43, April 2018, Pages 196-205
Journal: Journal of Functional Foods - Volume 43, April 2018, Pages 196-205
نویسندگان
Shaodan Chen, Tianqiao Yong, Chun Xiao, Jiyan Su, Yifan Zhang, Chunwei Jiao, Yizhen Xie,